Orient were left to curse missed opportunities as they let slip a lead to draw 1-1 with Fleetwood.
Darius Henderson gave the O's the lead with a thumping first half header before they were pegged back by Fleetwood sub Stephen Dobbie.
Russell Slade's side will be disappointed not to have taken all three points though after they twice rattled the woodwork and had late chances to win it.
Following the magnificent victory at Aston Villa on Wednesday, Russell Slade again shuffled his pack as Adam Legzdins returned in goal and in front of him Scott Cuthbert and Nathan Clarke took up their spots in a familiar looking defensive line-up.
Jobi McAnuff returned to the right hand side of midfield in place of Bradley Pritchard and the midweek hero Romain Vincelot took the spot of Marvin Bartley in the centre.
Having been rested on Wednesday, Darius Henderson was preferred up front alongside David Mooney as Orient looked to peg back the Cod Army who have set the early pace in League 1.
The wind swirled around Highbury and though Orient controlled the early possession, Legzdins was the first goalkeeper to be called into action when he brilliantly denied Stephen Crainey who had burst through on the overlap from left back.
Barely five minutes later the O’s ‘keeper was called into action again as he made a reaction save before diving at the feet of Jamie Proctor.
The scare seemed to spark Orient into life as Dean Cox and Mooney combined well and both had shots blocked before a McAnuff cross was cleared to Clarke who tried a dipping volley that went just over the bar.
The first half wind was against the O’s and made it difficult at times for them to clear their lines but they looked a threat from set-plays and were a whisker away from grabbing the lead with 25 minutes played when a McAnuff corner was met by the head of Mathieu Baudry who sent a header crashing against the post.
Orient started to look more of a threat in the final third and six minutes later Mooney did well to tee up Henderson but with no power on the bouncing ball he could only head tamely at Chris Maxwell. A minute later though, Cox sent in a great cross that the striker headed straight at Maxwell again.
The big striker wasn’t about to waste a third opportunity though and when McAnuff swung a deep ball in from the right with 10 minutes of the half remaining, the forward rose highest to thump a header down underneath Maxwell and give his side the lead.
There was still time for Lloyd James to test Maxwell from distance as Orient headed down the tunnel at half-time with a 1-0 lead.
Orient had the wind blowing in their favour after the interval yet found themselves on the back foot for much of the opening exchanges.
With 10 minutes of the second period gone, the home side thought they had levelled it when Legzdins could only parry a shot from Gareth Evans into the path of the dangerous Jamie Proctor who rolled it home only for the offside flag to go up.
The O’s were thankful to Vincelot 10 minutes later when he nicked the ball from Antoni Sarcevic who looked poised to shoot but within a minute Orient almost sealed it.
Henderson brought the ball down well and fed Cox on the left who picked out Mooney with a perfect cross that the Irishman glanced against the bar with a header.
Chances were fewer and farther between than in the first half but Orient deserved credit for the way they worked without the ball and were looking comfortable when Fleetwood sub, Stephen Dobbie, grabbed a leveller.
Orient failed to clear in midfield and the ball fell kindly for Dobbie who composed himself and slotted past Legzdins.
The O’s could have sealed it though within a minute when Cox fed Mooney but the striker bent his effort high and wide before a moment of controversy when Jay Simpson appeared to be in on goal but the referee brought the play back for an earlier foul on Omozusi.
It finished 1-1 to cap a long week of travelling for the O's supporters.
FLEETWOOD: Maxwell, McLaughlin, Pond (C), Evans, Schumacher, Morris, Sarcevic (Blair 82), Proctor, Ball (Dobbie 71), Jordan, Crainey
Subs: Davies, Murdoch, Roberts, Hogan, Campbell
Goals: Dobbie 82
Bookings: Schumacher 66, Proctor 89
ORIENT: Legzdins, Omozusi (Lowry 87), Vincelot, Cuthbert, Baudry, Cox, James, Mooney, McAnuff (Pritchard 73), Clarke (C), Henderson
Subs: Lee, Bartley, Dagnall, Simpson, Woods
Goals: Henderson 35.
Bookings: Cuthbert 29, Clarke 80
Ref: R Clarke
Attendance: 3,222 (434)