After a third straight league win against Morecambe, The O's will continue their run of winning home games - and look to add another three points.
Leyton Orient: 16. Ryan Allsop, 2. Leon McSweeney, 3. Gary Sawyer, 4. Ben Chorley, 7. Dean Cox, 8. Anthony Griffith, 9. Kevin Lisbie, 11. Jimmy Smith, 15. Nathan Clarke (capt), 21. Lee Cook, 22. Martin Rowlands
Subs: 6. Mathieu Baudry, 10. Michael Symes, 14. Marc Laird, 17. Moses Odubajo, 23. Lloyd James, 26. Ryan Brunt, 39. David Mooney
Sheffield United: 1. Mark Howard, 5. Harry Maguire, 6. Matthew Hill, 7. Ryan Flynn, 8. Michael Doyle (capt), 10. Nick Blackman, 11. Kevin McDonald, 14. Dave Kitson, 23. Paul Gallagher, 29. Tony McMahon, 30. Marcus Williams
Subs: 2. Darryl Westlake, 9. Chris Porter, 12. Shaun Miller, 16. David McAllister, 17. Richard Cresswell, 25. George Long (GK), 26. Callum McFadzean
Referee: David Phillips