It's box office viewing in E10 on Tuesday night, as league leaders Cambridge United head to the Breyer Group Stadium.
ORIENT have been drawn away to face Northampton Town in the area quarter finals of the Johnstone’s Paint Trophy.
The O’s booked their place in the last eight of the southern section by defeating Barnet on Tuesday, while the Cobblers saw off League 1 club Colchester United 2-1.
The game will take place at the Sixfields Stadium in the week commencing December 3. Check leytonorient.com for full fixture details.
Full draw
Northern Section
Crewe Alexandra v Doncaster Rovers
Bury v Preston North End
Port Vale v Bradford City
Coventry City v Notts County or Sheffield United
Southern Section
Northampton Town v Leyton Orient
Southend United v Brentford
Torquay United or Yeovil Town v Wycombe Wanderers
Plymouth Argyle v Oxford United