After a third straight league win against Morecambe, The O's will continue their run of winning home games - and look to add another three points.
Northampton Town: 21. Lee Nicholls, 3. Joe Widdowson, 5. Kelvin Langmead (capt), 7. Ishmel Demontagnac, 8. Ben Harding, 9. Clive Platt, 12. Ben Tozer, 17. Jake Robinson, 19. Louis Moult, 23/ Danny East, 28. Emyr Huws
Subs: 10. Adebayo Akinfenwa, 11. Chris Hackett, 13. Dean Snedker (GK), 15. Henoc Mukendi, 22. Lewis Hornby
Leyton Orient: 1. Jamie Jones, 2. Leon McSweeney, 3. Gary Sawyer, 5. Scott Cuthbert, 6. Mathieu Baudry, 7. Dean Cox (capt), 8. Anthony Griffith, 17. Moses Odubajo, 23. Lloyd James, 26. Ryan Brunt, 39. David Mooney
Subs: 10. Michael Symes, 11. Jimmy Smith, 16. Ryan Allsop (GK), 20. Afolabi Obafemi, 27. Alex Smith
Referee: Mark Haywood