The O’s have been drawn at home to Scunthorpe United in the second round of the FA Cup.
Having secured their progress to the second round with a 6-1 win over Staines Town, Orient will come up against League One opposition in the shape of Mark Robins’ Scunthorpe.
It could also see the return of former O’s striker Darius Henderson, who following his release from Orient linked up with the Iron in the summer.
The two sides have never met in the FA Cup but shared the spoils last season in League One, with the O’s winning 2-1 at Glanford Park, before the Iron won the return at the Matchroom Stadium 4-1.
The tie is due to be played between December 4-7, and a date for the fixture will be announced in due course.