After a third straight league win against Morecambe, The O's will continue their run of winning home games - and look to add another three points.
Leyton Orient player-manager Kevin Nolan admitted his side made too many mistakes as they sufferedf a first defeat in three games.
Ben Williamson put the U’s in front, before doubling his and Cambridge’s tally eight minutes into the second half.
Substitute Armand Gnanduillet pulled a goal back with his first for the Club, but it was to prove in vain as Jimmy Spencer sealed victory for Shaun Derry’s side.
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