The O’s are eyeing an FA Cup First Round victory when making the trip to League One side Sheffield United on Sunday (2pm kick-off).
Alberto Cavasin’s side lost 2-0 last time out to Crewe after goals from George Cooper and Harry Davis sealed defeat, and saw us slip to 23rd in League Two.
The Blades are flying high in League One, coming into the Cup encounter in fourth place, and have not tasted defeat in the league since a 2-1 loss at Millwall on August 20.
Last time out, Chris Wilder’s side defeated MK Dons 2-1 having taken a fifth minute lead through Stefan Scougall.
Darren Potter levelled matters for the visitors before Billy Sharp popped up with his 10th goal of the season to secure all three points.
At home, Sheffield United have only lost once all season in the league, and that was back on August 17 when losing 3-0 to Southend United.
The two sides have met before in this competition, with the Blades picking up a 4-1 win at the Matchroom Stadium back in 2009.
JJ Melligan had given the O’s a first half lead, before Greg Halford’s brace and one apiece for Billy Sharp and Kyle Naughton sealed victory for the Yorkshire outfit.
The O’s will be without defender Yvan Erichot who misses out with a groin injury, but are hoping to welcome back striker Paul McCallum and defender Aron Pollock to the matchday squad.
The duo returned to training this week ahead of the Cup tie, while Ulrich Nnomo is likely to miss out with the ankle injury he picked up in Saturday’s 2-0 home loss to Crewe Alexandra.
Midfielder Liam Kelly remains a long-term absentee following surgery on his torn hamstring he suffered in the Luton Town defeat.
AHEAD OF THE GAME
O’s boss Alberto Cavasin previews the FA Cup tie- here
Defender Nicky Hunt looks ahead to the trip to Bramall Lane – here
BETTING (Odds correct at time of preview)
The O’s are Sky Bet’s 6/1 outsiders for the FA Cup tie at Bramall Lane, while the Blades are 4/9.
Billy Sharp has 10 goals to his name so far this season and is priced at 11/4 to score the opener at the weekend, while Ollie Palmer and Jay Simpson lead the market for the O’s, with both strikers available at 9/1.
Last time out the O’s drew 2-2 at Bramall Lane in League One in 2015, and a repeat of that scoreline is priced at 16/1.
Not able to make the game? Follow updates on the O’s official Twitter feed or follow commentary on the game listen to BBC London’s Dave Victor on Orient PlayerHD.
Match Report and reaction following the game will appear on leytonorient.com.