Orient ended the first half a goal ahead thanks to Charles Clayden and the O’s added to their lead further midway through the second half through Eric Lopes and Ruel Sotiriou.
There were two changes to the starting XI, Amin Benyoucef and Sam Dalby returned to the side in place of Brendon Shabani and Eric Lopes who dropped to the bench.
The opening chance of the game fell to Sam Dalby, who latched on the end of Ruel Sotiriou’s square ball, but the striker’s effort was blocked by the feet of the ‘keeper and then cleared away from danger.
Arthur Janata was forced into action early on, when he raced off his line to bravely punch away an early cross swung into the box from the right wing.
The hosts enjoyed large spells of possession in the first half, and had two chances just shy of the half hour mark.
The first came from Glory Bello, who cut in from the right wing and curled a low shot towards goal, but the ball rolled just past the post.
The second chance was an acrobatic scissor kick after a corner ball was crossed into the area, but the effort was collected well by Janata.
Moments later, a switched ball from Toby Stevenson released Alfie Fleming down the left who played Charles Clayden into the box. Clayden then unleased a low shot into the far corner from a tight angle to give the O’s the lead.
Soon after the restart, Amin Benyoucef collected a quick free-kick and darted towards the box, his attempted shot was deflected just wide of the target.
The O’s looked the more comfortable side in possession after an hour, and stepped up their search for a goal going close on a number of occasions.
Ernold Haxhiu’s looping header from the edge of the box was tipped just over the bar by Tower Hamlets ‘keeper Ethan Bailey.
Orient were denied again, this time Benyoucef chipped a shot towards the back post after linking up well with Dalby. But the midfielders shot hit the top of the bar and bounced behind for a goal-kick relieving the pressure on the hosts.
The O’s thought they had scored but Eric Lopes’ touch from a corner was ruled out for offside and the goal was disallowed.
The set-back didn’t hinder Orient’s attacks however, after Haxhiu’s header was parried away for a corner, Lopes was on hand again to bundle home a corner floated in by Benyoucef.
Two minutes later Sotiriou made it 3-0 when he done well to place the ball past the ‘keeper after he had picked up a square ball from Charles Clayden just inside the box.
Still comfortable in possession, the O’s saw out the remaining minutes with little pressure from the hosts until the final whistle sounded.
The victory means the O’s will now host AFC Hornchurch in the next round of the FA Youth Cup (date to be confirmed).
Speaking after the match captain Teddy Perkins said; “We could’ve made it hard work for ourselves in the first half, but we got the goal and just stayed on top from then. The goal was against the grain, but when we got it we hung on and then when they became tired in the second half and we slotted two more away.
“It’s much more positive in the dressing room now, we were going through a tough patch but we’ve come through it, hopefully we’ve seen the back of it and can start putting some good performances together and get some wins.”
ORIENT: Arthur Janata, Andrew Camilo-Tayaca, Teddy Perkins, Toby Stevenson, Alfie Fleming, Ernold Haxhiu, Amin Benyoucef (Brendon Shabani 79), Charles Clayden, Jaedon Phillips (Eric Lopes 45), Sam Dalby, Ruel Sotiriou (Hector Kyprianou 85)
SUBS: Samuel Amedu, Luca Carter-Henry
Goals: Clayden (31), Lopes (71), Sotiriou (73)