Orient come into the game on the back of a 1-0 defeat to league leaders Macclesfield Town on Saturday.
Scott Wilson headed home from close range on the stroke of half time to give the visitors the lead, and the Silkmen held on despite a number of O’s chances to claim all three points.
Gateshead arrive in E10 having had an almost identical start to the season to the O’s, sitting above the O’s on goal difference.
The Heed lost 3-2 to Eastleigh on Saturday with new manager Steve Watson denied a point in his first league match thanks to Ben Strevens 95th minute winner.
The Tynesiders finished in 8th position in the National League last season.
Ruel Sotiriou and James Brophy impressed after coming off the bench in Saturday’s defeat to Macclesfield Town and will be hoping for more involvement on Tuesday.
The O’s are also hopeful that midfielder Jobi McAnuff will be fit following a spell out with a groin injury.
However, midfielder Alex Lawless and striker Matt Harrold remain doubts with respective groin and cinjury.
Head Coach Steve Davis after Saturday’s defeat to Macclesfield – here.
Midfielder James Brophy reflects on the O’s home defeat at the weekend – here.
Can’t make the game? Follow live updates through the official Twitter feed, or listen to audio commentary from Dulcet Dave on Ozone.
Audio commentary will be available through the match centre which will appear at the top of the leytonorient.com homepage, with commentary starting 30 minutes before kick-off.
Match report and reaction following the game will appear on leytonorient.com.