Justin Edinburgh’s men travel to Cheshire on the back of a 4-1 win over Barrow AFC, when a Macauley Bonne brace and Josh Koroma goal wrapped up the three points for the O’s.
Macclesfield host Orient on the after a 0-2 win at Boreham wood on Tuesday night, Tyrone Marsh’s double pushed The Silkmen 12 points clear at the top of the National League table.
The last time the two sides met was back in October, when a single Scott Wilson goal slumped the O’s to defeat.
Orient have been in good form of late and after last weekend’s home win the O’s made it three successive wins.
Forward Dan Holman is unlikely to feature for the O’s this weekend after he sustained an injury to his foot in the Guiseley fixture.
Central defender Josh Coulson is likely to be out for a spell on the side-lines after he suffered a toe injury in the 4-1 win over Barrow AFC last weekend.
Otherwise, Edinburgh should have a near full-strength squad to select from, defender Marvin Ekpiteta could make his first start after his home debut performance in the win over Barrow on Saturday.
IN THE BUILD UP
Assistant Coach Ross Embleton previews the Macclesfield clash – here
Defender George Elokobi looks ahead to this weekend’s fixture – here
All ticket information for tomorrow’s fixture can be found here.
Can’t make the game? Follow live updates through the official Twitter feed, or listen to audio commentary from Dulcet Dave on Ozone.
Audio commentary will be available through the match centre which will appear at the top of the leytonorient.com homepage, with commentary starting 30 minutes before kick-off.
Match report and reaction following the game will appear on leytonorient.com.