The hosts levelled moments before half-time, before two second half goals were enough to gift The Hatters victory.
Key figures such as Jaedon Phillips and Brendon Shabani returned to the O’s line-up. Jayden Sweeney re-joined the squad after representing the first team for his second appearance against Wrexham.
The hosts created multiple shooting opportunities in the opening stages but failed to hit the target.
Anthony Papadopoulous registered Orient’s first effort on goal with a superb individual effort. Winning the ball on the half-way line, the right-back ran at the opposite defence, before pulling the trigger from range, after a smart one-two with Phillips. The low effort was matched by The Hatters Keeper.
It would be the O’s who took the lead after 18 minutes, Clayden hammering home a dead ball, after Lawrence Hammond was brought down on the edge of the area. Slightly right of centre, Clayden’s effort give Orient the perfect start, as the winger pinged the ball into the top corner of the net with his left foot.
Amedu was to make his first save of the game six minutes later, he blocked a volley from the edge of his penalty area.
Shabani may have bagged a second goal for Orient, before the half-hour mark, but the midfielder flashed an effort wide after picking up a loose ball in the 18 yard-box.
Sweeney played a neat ball into Clayden, who looked to bag a brace before half-time as he cut in to the box from the flank, shooting with his weaker right-foot but failing to hit the target.
Luton equalised on the stroke of half-time with a set piece of their own. A delivery deep from the right flank was flicked into the top corner by the forward who attacked the ball well.
Little under ten minutes into the second-half, Mason Hall made a vital clearance off the line to keep the score-line level. Amedu did well to block a fierce effort, but the pace of the ball carried it behind him, but Hall was on hand to slide and clear the ball off the line.
Set pieces were proving to be dangerous for both sides, but it would be the home sides turn to score directly from a free-kick. From the right hand side of the area, the taker curled the ball low into the bottom corner at Amedu’s near post after 70 minutes.
The game’s first goal from open play came after 76 minutes, as the hosts countered. Some direct passing saw defence turn into attack, as a long ball was taken down by Luton’s number nine, before the striker fired past Amedu.
Phillips came close to pulling a goal back for his side, but was denied by a save from the opposition Goalkeeper. Substitute Finlay Lovatt slotted his striking partner through on goal, but Phillips effort from close range was saved.
The game fizzled out and the referee blew his whistle, with two second half goals the difference between the two sides.
The O’s are back in action this Saturday morning, when they welcome Peterborough United to the Whitbreads Sports ground.
ORIENT: Sam Amadu, Anthony Papadopoulous (Ernold Haxhui 63’’), Mason Hall, Wynford Marfo, Jayden Sweeney, Jeremie Sivi, Bradley McCleneghan (Finley Lovatt 77’’), Brendon Shabani, Charles Clayden, Jaedon Phillips, Lawrence Hammond (Amin Benyoucef 63’’)
GOALS: Clayden 18’