Justin Edinburgh’s men overcame Wrexham by a single goal in the previous round thanks to Matt Harrold’s second half penalty.
Blyth Spartans come in to the fixture having defeated National League opposition in Boreham Wood to progress.
Most recently for Orient was a three-goal victory over Maidstone United thanks to a Macauley Bonne brace and single goal from Jordan Maguire-Drew, his first for the O’s.
Blyth travel to E10 in good form, having tasted defeat for the first time in 14 games last weekend late goals from Kieran Green and Bradley Fewster couldn’t protect their unbeaten run any further.
Josh Koroma was earlier this week, ruled out for a minimum of three weeks of action following a hamstring injury last time out against Maidstone United.
The FA Trophy may give Edinburgh an opportunity to rotate the squad and rest some players with the likes of Matt Harrold, James Alabi, Alex Lawless and Dale Gorman all pushing for a starting place.
The Club earlier announced Shadrach Ogie was involved in the 20-man squad for tomorrow’s game having recently received international clearance.
Watch episode 25 of The O’s Show featuring Macauley Bonne who talks goals and a preview ahead of this weekend with Ross Embleton here.
The referee for today’s fixture against Blyth Spartans is Lloyd Wood, he will be assisted by Dan Bonneywell and Christopher Myatt with Oliver Jackson as the fourth official. Wood took charge of our earlier fixture at Dover Athletic and awarded the home side a penalty in the opening stages of that game. In total, the local official has been in charge of 13 National League games, handed out 33 yellow cards, four red cards and three penalties this term.
Fans outside the UK, whether O’s fans or Blyth supporters can purchase a day pass here to watch this game for just £6.99.
Please note this service is only available to fans outside the UK. For those unable to attend this cup game, full match commentary will be available as normal through Ozone.