The visitors, in their green and white strip got the tie underway, as the sun beamed down on the two sides.
The O’s first effort would come from the Captain. Bradley McClenaghan looked to open the scoring with a strike from distance, but fired wide after carrying the ball 30-yards from his own half of the pitch.
22 minutes into the first-half, Plymouth took the lead. Possession was won back by the visitors and a sharp counter led to their first effort on target, which whistled into the bottom corner.
Argyle had the ball in the net 60 seconds later having worked a free-kick well, but the linesman raised his flag as soon as the ball was stabbed home.
Orient’s efforts to find an equaliser before half-time were nearly rewarded as a last-ditch block denied Lawrence Hammond a goal. Jayden Sweeney found Jayden Young with a driven pass, whose turn left the defence for dead. Young then picked out Hammond in the penalty area but his left footed effort was blocked.
Aridas Vilinauskas ensured it would be just a one goal difference at the break, clawing an effort away from his top right corner, as Plymouth finished the half strong.
Following the restart, Jeremie Sivi raced in behind after been found by a superb ball from Kyrell Palmer. Sivi took one touch before pulling the trigger from a tight angle, but the keeper was equal to his effort.
Hammond displayed great determination to fashion a shooting chance on the hour, beating his marker before bending an effort goal bound, only to see a defender clear the ball.
A second goal for Plymouth came against the run of play. A long ball exposed space in behind the O’s defence and the pursuing forward fired the ball into the bottom corner.
Vilinauskas was busy soon after, making a splendid double save to keep the score at 2-0. A fizzing shot smashed back off his chest, before he pounced back-up to block the ball at the forwards feet.
The visitors came again and should have really put the tie to bed, but their striker couldn’t find the target after a teammate found him in space in the penalty area.
With time ticking away The O’s chased every last ball but couldn’t conjure a consolation as time ran out.
Next Up: Orient travel to Bristol as they take on Bristol Rovers on April 6th.
ORIENT: Aridas Vilinauskas, Kyrell Palmer(Ben Young 69”)Wynford Marfo, Trialist, Jayden Sweeney, Jeremie Sivi (Tom Mulqueen 69”)Brad McClenaghan, Brendon Shabani, Brian Ifeanyi (Jordan Adeyemi 60”) Lawrence Hammond, Jayden Young (Lukas Rolfe 60”)
BOOKED: McClenaghan 65”