After a point against Port Vale on Saturday, the O's are in midweek action with a trip to Bradford City.
Leyton Orient will visit Essex Senior League side, Tower Hamlets, in the London Senior Cup.
The O’s enter the Second Round of the competition and will face the Hamlets on September 24, with a 19:45 kick-off.
The game will take place at Mile End Stadium, E14 7TW.