Ross Embleton leads the O’s as Interim Head Coach for the final time, following the appointment of Carl Fletcher, as he aims to stretch an unbeaten run to four games, having picked up seven points against Port Vale, Northampton and Walsall in previous outings.
Last time on the pitch, Orient came from behind to see-off Walsall 3-1 at The Breyer Group Stadium with Joe Widdowson netting his first goal for the Club on his 100th appearance.
The left-back had levelled things early in the second half before Matt Harrold bagged his first of the season and Conor Wilkinson scored his fourth goal of this League Two campaign.
The hosts come into the game two points above Orient in 10th place but have lost their last three games, two coming in the league.
Last Saturday, the Mariners fell foul to Stevenage, who claimed their first win of the season, with Ahkeem Rose netting a consolation.
Conor Wilkinson serves the first of his three-game suspension having seen red against Walsall last weekend for an off-the-ball incident with Dan Scarr.
Sam Ling and Marvin Ekpiteta will be assessed before Saturday as they aim to recover from groin and hamstring problems respectively.
Lee Angol, Jamie Turley and Jobi McAnuff continue to make steps in the right direction, though remain unavailable through injury.
Nicholas Kinseley will officiate the game on Saturday, Paul Newhouse and David Hunt will be the Assistant Referees and Stephen Wade will be Fourth Official.
Kinseley has taken charge of seven fixtures this season, five of which in League Two, booking 22 players, sending-off three and awarding three penalties.
He last officiated the O’s back in 2017 as Cambridge United won the League Two fixture 3-0. The Referee booked one Orient man that day: Liam Kelly.
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Match report and reaction following the game will appear on leytonorient.com.