Jamie Turley skippered the O’s as young first-team players Jayden Sweeney, Myles Judd and Shadrach Ogie started in the London Senior Cup.
The experienced defender had the first opportunity of note in the 21st minute when he headed wide from Papadopoulos’ free-kick, although the assistant’s flag was up at the far side.
A quick counter attack from the home side in the 28th minute had Reece Mitchell in the box in space but his effort was fairly comfortable for Arthur Janata.
It was the men in green who took the lead in the 32nd minute when Connor Calcutt raced onto a Reece Mitchell pass, cut inside and rifled past Janata into the far corner.
They continued to look a threat as Calcutt found himself in a good position from a drilled cross but the striker missed his flick-on and the O’s cleared.
Myles Judd was booked a minute before half-time when he bundled over a home attacker as he broke away along the right touchline.
The O’s needed a response in the second half and almost got it when Hammond chased down a defensive header and almost bundled the ball goal-wards but the defender just about scrambled it away.
Jordan Adeyemi came on for Finlay Lovatt just before the hour mark and he had an opportunity immediately, racing on to Hammond’s flick on but the forward side-footed wide.
Myles Judd struck from distance in the 70th minute but his effort was deflected, taking the sting out and Todd collected comfortably.
Hendon won a free-kick on the edge of the box in the 78th minute following a Judd collision. Galliford stepped up and drilled an effort at goal but Janata did well to palm away.
Brian Ifeanyi had a chance minutes later as he worked some space on the right side of the box but his low effort was well saved by Todd.
The O’s couldn’t complete a comeback as the home side held on for a narrow win.
LEYTON ORIENT: Janata, Marfo (Sanders 81’), Sweeney, Judd, Turley, Ogie, Sivi, Papadopoulos, Hammond, Lovatt (Adeyemi 57’), Ifeanyi (Dunbar-Bonnie 87’)
SUBS: Campbell, Francois-Vernal, Adeyemi, Dunbar-Bonnie, Sanders
BOOKED: Judd (44’)