The O’s will be looking to bounce back from the 1-0 defeat they suffered at the hands of Port Vale at the weekend.
After weathering an early storm, Ross Embleton’s side began to grow into the game at Vale Park, with both Josh Wright and George Marsh coming close.
It was the home side who found the only goal of the game though, when former Liverpool winger David Amoo fired in from the edge of the box in the 71st minute.
Northampton come into this fixture in a fine run of form having notched up four consecutive wins in all competitions.
The most recent of those came on Saturday when they defeated Morecambe 4-1 at Sixfields, with former O’s loanee Nicky Adams bagging a goal and an assist.
That victory saw them move up to 6th place in League Two, and in Keith Curle they have a manager with experience of reaching the playoffs in this division, having done so with Carlisle in 2017.Tickets
Tickets are available to buy on both the East and South stand cash turnstiles.
Ouss Cissè and Lawrence Vigouroux could push to start their first game for the O’s after both the new signings made the bench at the weekend.
Jamie Turley, Jobi McAnuff and Dean Brill remain out.
The two sides last met back in October, with Orient running out 1-0 victors away from home.
James Brophy scored the only goal of the game in the 59th minute when he latched onto Matt Harrold’s through ball and slotted past David Cornell in the Cobblers net.
Referee: Alan Young
Assistant Referees: Paul Lister and Nicholas Cooper
Fourth Official: Leigh Crowhurst
Alan Young has refereed 17 EFL fixtures so far this term, with 10 coming in League Two. In those 17 games he has handed out a total of 81 yellow cards and two reds.
He last oversaw Orient in the 1-1 draw with Oldham at Boundary Park last month. Marsh, Joe Widdowson and Dan Happe all saw themselves cautioned in that one.
Can’t make the game? You can follow live updates through the Club’s Twitter feed. Post-match reaction will also appear on leytonorient.com shortly after the final whistle.
Both overseas and domestic fans can watch the match via the Orient TV Live-Stream, sponsored by The Lion and Key Hotel. Alternatively, you can listen to the audio stream, with commentary from Dave Victor, for just £2.50.