The O’s pulled further away from the bottom of the table with a resounding 3-0 win against Stevenage on Saturday.
Ruel Sotiriou opened the scoring for the O’s in the 19th minute with a fierce strike that beat Stevenage keeper, Paul Farman at his far post.
Ouss Cissè doubled Orient’s lead with his first goal for the club just before the hour mark, prodding home from Josh Wright’s free kick. Before Sotiriou rounded off a fine performance with a fine solo goal minutes later.
Macclesfield are without an away win since October and come into this one off the back of two narrow defeats.
Before losing out by a single goal to both Newport and Northampton, they had picked up a couple of impressive home results first drawing 1-1 with Crewe then defeating Forest Green 2-1.
Those results leave the Silkmen 22nd in League Two, six points off the one relegation spot.
James Dayton will be available for selection after serving his three match ban, for a straight red card picked up against Northampton Town
Louis Dennis continues to struggle with a niggle in his knee, keeping the forward from making a full recovery to match fitness.
Sam Ling, Jamie Turley, Kazaiah Sterling and Jobi McAnuff remain out injured.
Orient were brought crashing back down to earth following their return to the Football League in the last meeting between the two sides.
Theo Archibald, Emmanuel Osadebe and Theo Vassell all netted for the Silkmen in a 3-0 win over the O’s at Moss Rose back in August.
Referee: Nicholas Kinseley
Assistant Referees: Stephen Brown and Oliver Jackson
Fourth Official: Marc Wilson
Kinseley has officiated 16 EFL fixtures so far this term, with 11 coming in League Two. In those games he has handed out 46 yellow cards and three reds.
He last took charge of an Orient game back on Boxing Day in the 3-1 defeat to Colchester United. Josh Wright, Jordan Maguire-Drew and Craig Clay all picked up yellow cards in that one.
Can’t make the game? You can follow live updates through the Club’s Twitter feed. Post-match reaction will also appear on leytonorient.com shortly after the final whistle.
Overseas fans can watch the match via the Orient TV live stream, sponsored by The Lion and Key Hotel for just £5, while domestic fans can listen to the audio stream, with commentary from Dave Victor, for just £2.50.