The O’s will host The Pilgrims on Tuesday 15th September, with a 19.45pm kick-off scheduled at the Breyer Group Stadium.
Both clubs will be keen to progress in the competition, with a high-profile home clash with Tottenham Hotspur awaiting the winners.
The game will be behind-closed-doors, and the only way to watch the game will be through our streaming service, Orient Live.
Passes are on sale now, at £10 for UK viewers. Due to competition broadcasting rights, the tie is not available overseas as things stand.