League One Plymouth Argyle make the trip to The Breyer Group Stadium, with both teams vying for a place in the Carabao Cup Third Round.
Awaiting the winner? Jose Mourinho’s Tottenham Hotspur, in a high-profile home tie.
With Orient in good form thus far, it’s sure to be a cracker of a game – and one you can watch it all unfold on Orient Live, our enhanced streaming service.
Regular host Ollie Buck will be joined by former Orient defender John Mackie in the studio, as they bring you pre-match, half-time, and post-match analysis.
Leyton Orient v Plymouth Argyle: 7.45pm kick-off Tue 15th September – Passes are on sale for just £10, by clicking here.
Please note, due to international broadcasting rights, the game is not available to purchase for overseas supporters.