The Hammers will visit the Breyer Group Stadium on Tuesday 13th July, with a 7pm kick-off time.
David Moyes’ will see his first-team squad split into two, with another friendly also set to be played on the same evening.
West Ham will come off of the back of a successful season, having achieved European qualification from their sixth-placed league position.
This fixture follows on from the announcement that Orient will host Gillingham, on Saturday 31st July.
Ticketing and hospitality details for the fixture will be shared with supporters in due course.