The London derby will kick-off on Wednesday 11th August at 7.45pm at the Breyer Group Stadium.
It will be the first meeting between the two sides in 14 years, when goals from Adam Boyd and Jason Demitirou sealed a win for The O’s at Loftus Road in the same competition.
Ticketing details for the game will be announced in due course, in what will be the first home game for Kenny Jackett’s Orient side.
Both Kenny Jackett and Assistant Manager Joe Gallen worked for The R’s at the start of their management careers, whilst recent signing Paul Smyth joins Orient from W12.
The cup clash will follow on from Leyton Orient’s opening day game with Salford City at the Peninsula Stadium, after the fixtures were announced last week.
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