Orient will kickstart their cup campaign against Southampton U21’s, at The Breyer Group Stadium. Kenny Jackett’s team will then travel to The People’s Pension Stadium to face league rivals Crawley Town for their second group match, before welcoming Charlton Athletic to E10.
Tuesday 14 September 2021. Kick-off 7pm
Leyton Orient v Southampton U21
Tuesday 05 October 2021. Kick-off 7pm
Crawley Town v Leyton Orient
Tuesday 09 November 2021. Kick-off 7pm
Leyton Orient v Charlton Athletic