Kenny Jackett will be expected to make changes to his side, with previous PJT match winner Antony Papadopoulos hoping to earn himself another starting berth.
Paul Smyth will miss out having joined up with the Northern Ireland international team, whilst the game will come a little too soon for Adam Thompson.
Alex Mitchell will likely miss out again with a hamstring injury remaining monitored, whilst Callum Reilly continues his rehabilitation.
Crawley come into the fixture in a good vein of form, losing just once in their last five games, and finding themselves in 14th position.
Whilst experienced keeper Glen Morris has featured in all ten league games so far this season, new signing Dillon Curtis-Henry is expected to make his first start, after signing recently on a rolling contract.
His signing comes following the injury to Blondy Nna Noukeu, with the onloan keeper picking up a shoulder injury.
Whilst The O’s overcome Southampton 1-0 in their first fixture of the group, it wasn’t as straightforward for Crawley.
Town travelled to SkyBet League One side Charlton Athletic and suffered a large defeat, with the Addicks coming out as 6-1 winners.
The game wasn’t as the scoreline might suggest though, with Crawley having more shots, shots on target and even possession – but couldn’t transfer it to a meaningful result.
Tickets are on sale from Crawley Town on the evening, but for those who can’t make it, streaming is available worldwide.
The show will begin at 6.40pm, with kick-off set for 7pm.