Harry Redknapp's Premier League side travel to E10 for a friendly on July 29
The R's won promotion back to the Premier League last month when they overcame Derby County at Wembley in the Championship Play-Off Final.
Managed by Harry Redknapp, Rangers' squad boasts the likes of Joey Barton, Charlie Austin, and Rob Green as well as a host of international stars.
The game will kick-off at 7:45pm kick-off with full ticket details to follow. The game will replace the friendly with Dagenham & Redbridge in the original schedule.
Orient will travel to Conference South side Dartford on Friday July 18, before another away friendly at Conference Premier Play-Off Final runners-up Gateshead on Wednesday July 23.
Full ticket details, kick-off times and further fixtures will be announced in due course on www.leytonorient.com
Andy Edwards' U18s side have the following fixtures - all away from home - confirmed:
Charlton Athletic 19th July KO tbc (CA training ground)
Hadleigh Town 26th July KO 1PM
West Ham 29th July KO 11am (WH training ground)