The O’s go into the game on a three-match unbeaten run, and last time out came from 3-1 behind to pick up a point thanks to Josh Wright’s second goal in as many games.
Crewe have won two of their last 11 games, but those victories did come against fellow strugglers Scunthorpe United 2-0 and an impressive 2-1 success at play-off hopefuls Sheffield United.
In the reverse fixture, the O’s recorded an impressive 4-1 victory, with a double from Chris Dagnall and one each for Dean Cox and David Mooney and Orient will look to secure their third league double of the season.
Last year, Dagnall was once again the hero as he came off the bench on his debut to help the O’s come from behind to secure a 2-1 victory with another double, while Moses Odubajo and Mooney netted in a 2-0 home win last term.
Orient will be without left back Gary Sawyer after picking up an injury in the victory over Port Vale, and he joins long-term absentees Adam Legzdins (shoulder) and Romain Vincelot (knee) on the sidelines.
Crewe will be without Anthony Grant, the scorer of the consolation goal in the reverse fixture, who is serving the second game of a two-match ban.
Tickets are available on the day for the O’s trip to Gresty Road, and for more details click here.