All the information ahead of the O's latest League Two encounterLeyton Orient will be looking to build on last weekend's victory at Portsmouth tomorrow when they host League Two leaders Northampton Town at the Matchroom Stadium.
Kevin Nolan's side go into the tie in full confidence, having claimed a third win in four games under the 33-year-old with Jobi McAnuff's stunning second half strike giving the O's the win at Fratton Park.
The victory saw Orient move back into the Play-Off places up to sixth, but Wycombe's midweek win at Dagenham & Redbridge meant the O's dropped down a place ahead of this weekend's set of fixtures.
Northampton Town arrive in E10 sitting comfortably at the top of the League Two summit - five points ahead of second placed Plymouth Argyle.
Chris Wilder's side currently boast a perfect run with six league wins in as many games, and last Saturday claimed a 2-0 victory at home to York City.
John-Joe O'Toole put the Cobblers ahead midway through the first half, and captain Marc Richards sealed the points nine minutes after the restart before York had Luke Hendrie sent off two minutes later.
THE LAST TIME IN E10
Leyton Orient 2
Northampton Town 0
Johnstone's Paint Trophy
The long wait for a victory at the Matchroom Stadium finally ended when goals from Jay Simpson and Marvin Bartley saw off League two side Northampton Town in this Southern area quarter-final tie.
It was a maiden win under manager Mauro Milanese as Orient dominated early on and opened the scoring in the 28th minute when Chris Dagnall picked Jay Simpson out with a through ball and he drew out Cobblers goalkeeper Matt Duke before drilling home - it was the first time Orient had taken the lead at home in any competition.
In the second half Northampton Town squandered a number of chances with Kaid Mohamed, Chris Hackett and Marc Richards all failing to find the target before the O’s wrapped the game up on the stroke of full-time when Dagnall worked the ball into the path of Bartley and the midfielder placed his shot into the corner of the net from 15 yards.
ORIENT: Legzdins; Omozusi (Batt, 70), Lowry, Clarke, Sawyer, Pritchard, Bartley, Wright, Cox, Dagnall (Baudry 90+3), Simpson (Kashket 52)
SUBS: Woods, Plasmati
GOALS: Simpson (27), Bartley (90)
Leyton Orient will have midfielder Nigel Atangana available once again for the visit of Northampton having missed out on last weekend's 1-0 win at former Club Portsmouth.
Nicky Hunt and Shaun Brisley made their O's debuts in the impressive victory, and will both be looking to build on that by making their first appearances for the Club at the Matchroom Stadium.
Young forward Scott Kashket is a doubt however having picked up an injury in the Development League defeat at Premier League side AFC Bournemouth on Tuesday.
Meanwhile, long-term absentees Paul McCallum, Dean Cox and Lloyd James have all made positive strides this week with their rehabilitation programmes.
BETTING (Sky Bet Odds correct at the time of preview)
Leyton Orient are 11/8 with Sky Bet to win Saturday’s Sky Bet League Two clash with leaders Northampton Town, who can be backed at 2/1 with the draw 23/10. The O’s have won three of their last four under new player-manager Kevin Nolan, including an impressive 1-0 success at Portsmouth last weekend and a repeat of that scoreline can be backed at 13/2. All three of those wins have been either 1-0 or 2-0 and Sky Bet have Orient to win 1-0, 2-0 or 2-1 9/4, while the hosts to win by exactly one goal is 3/1.
Not able to make it today? Follow coverage of the game on the O’s official Twitter feed or keep up with every kick over on the Orient Wall. If you are looking for audio coverage, you can listen to commentary from BBC London’s Dave Victor on Orient PlayerHD.
Following the match head to leytonorient.com for match report and reaction.