The Club will travel to Sutton United on the opening day of the 2017-18 Vanarama National League season.
The O's will travel to Gander Green Lane on August 5, with the game kicking off at 12.30pm due to be chosen to be shown live on BT Sport.
Orient will then get their home campaign underway against Solihull Moors on Tuesday, August 8.
Boxing Day will see the O's host Dagenham & Redbridge at the Matchroom Stadium, with the reverse fixture being contested on New Years' Day.
The final day of the 2017-18 domestic season will see the O's travel to Gateshead on April 28.
The full list of fixtures can be seen below:
Sat Aug 5 Sutton United (A)
Tue Aug 8 Solihull Moors (H)
Sat Aug 12 Maidstone United (H)
Tue Aug 15 Bromley (A)
Sat Aug 19 Woking (A)
Sat Aug 26 Eastleigh (H)
Mon Aug 28 Maidenhead United (A)
Sat Sep 2 Guiseley (H)
Sat Sep 9 Boreham Wood (A)
Tue Sep 12 FC Halifax Town (H)
Sat Sep 16 Hartlepool United (H) Emirates FA Cup 2Q
Sat Sep 23 Aldershot Town (A)
Sat Sep 30 AFC Fylde (H) Emirates FA Cup 3Q
Tue Oct 3 Tranmere Rovers (A)
Sat Oct 7 Barrow (A)
Sat Oct 14 Emirates FA Cup 4Q
Sat Oct 21 Macclesfield Town (H)
Tue Oct 24 Gateshead (H)
Sat Oct 28 Wrexham (A)
Sat Nov 4 Emirates FA Cup 1
Sat Nov 11 Ebbsfleet United (A)
Sat Nov 18 Dover Athletic (H)
Tue Nov 21 Chester (H)
Sat Nov 25 Torquay United (A) Buildbase FA Trophy Q3
Sat Dec 2 Solihull Moors (A) Emirates FA Cup 2
Sat Dec 9 Sutton United (H)
Sat Dec 16 Buildbase FA Trophy 1
Sat Dec 23 Maidstone United (A)
Tue Dec 26 Dagenham and Redbridge (H)
Sat Dec 30 Bromley (H)
Mon Jan 1 Dagenham and Redbridge (A)
Sat Jan 6 Boreham Wood (H) Emirates FA Cup 3
Sat Jan 13 Buildbase FA Trophy 2
Sat Jan 20 FC Halifax Town (A)
Sat Jan 27 Aldershot Town (H) Emirates FA Cup 4
Sat Feb 3 Hartlepool United (A) Buildbase FA Trophy 3
Sat Feb 10 Tranmere Rovers (H)
Sat Feb 17 AFC Fylde (A) Emirates FA Cup 5
Tue Feb 20 Chester (A)
Sat Feb 24 Torquay United (H) Buildbase FA Trophy 4
Sat Mar 3 Dover Athletic (A)
Sat Mar 10 Ebbsfleet United (H)
Sat Mar 17 Eastleigh (A) Emirates FA Cup 6/Buildbase FA Trophy Semi-Final 1
Sat Mar 24 Woking (H) Buildbase FA Trophy Semi-Final 2
Fri Mar 30 Guiseley (A)
Mon Apr 2 Maidenhead United (H)
Sat Apr 7 Barrow (H)
Sat Apr 14 Macclesfield Town (A)
Sat Apr 21 Wrexham (H) Emirates FA Cup Semi-Final
Sat Apr 28 Gateshead (A)
Wed May 2 Play-Off Qualifying Round
Sun May 6 Play-Off Semi-Final
Sat May 12 Play-Off Final
Sat May 19 Emirates FA Cup Final
Sun May 20 Buildbase FA Trophy Final