The O's make the fairly short trip to Dover Athletic tomorrow (kick-off 3pm) in the Vanarama National League.
Justin Edinburgh's men fell to a 2-1 defeat away to Dagenham & Redbridge on Wednesday but retained a three point lead at the top of the National League.
The O's took the lead through Josh Koroma in the 73rd minute but the Daggers responded immediately as Alex McQueen slotted home before Ben Nunn's deflected effort three-minutes-from-time gave the O's just their third defeat of the season.
Andy Hessenthaler's side are on of the form teams in the league having claimed 13 points from their last six games, sitting outside the relegation zone on goal difference.
The White's came from behind on Wednesday to secure a win over Maidstone United, falling behind to Jake Robinson's first half effort. However, Mitch Brundle's header on the 59th minute levelled scores before Bedsente Gomis gave Dover Athletic the lead with 15 minutes to go. Inih Effiong made it 3-1 in the 80th minute.
The two sides last met in August as the O's claimed a 3-0 win at the Breyer Group Stadium. Jobi McAnuff opened the scoring on the 54th minute before Josh Koroma doubled the advantage on the 81st minute. Matt Harrold wrapped up the scoring with a header moments from time.
Midfielder Jobi McAnuff remains a doubt with the toe injury that kept him out of Boxing Day's defeat to Dagenham & Redbridge. Charlie Lee is available for contention despite being taken off with a head injury on Wednesday.
The match is pay on the day at the Crabble with no tickets available from the Breyer Group Stadium.
We have an allocation of 2,000 standing on the terrace and 110 seats
Prices are as follows:
Can’t make the game? Follow live updates through the official Twitter feed, or listen to audio commentary from Dave Victor on Ozone.
Audio commentary will be available through the match centre which will appear at the top of the leytonorient.com homepage, with commentary starting 30 minutes before kick-off.
Match report and reaction following the game will appear on leytonorient.com.